UNDATED (AP) -- The former Stanford quarterback beat his Cardinal head coach this afternoon.
Andrew Luck threw for 164 yards and ran for a big six-yard touchdown as the Indianapolis Colts knocked off Jim Harbaugh and the 49ers in San Francisco. The Colts were clinging to a 13-7 lead when Luck scored on a bootleg with 4:13 remaining, 78 seconds before Ahmad Bradshaw scored on a one-yard run to ice the victory.
Bradshaw rushed for 95 yards and newcomer Trent Richardson had a one-yard TD run as the Colts improved to 2-1.
Colin Kaepernick (KAP'-ur-nik) ran seven times for 20 yards and was just 13 of 27 for 150 yards and a late interception for the 1-2 Niners.
Seattle quarterback Russell Wilson was efficient in a 45-17 rout of Jacksonville, completing 14 of his 21 passes for 202 yards and four touchdowns. Zach Miller and Sidney Rice each had two scoring receptions before Wilson was replaced by backup Tarvaris Jackson in the third quarter. Jackson also put up impressive numbers in a brief appearance, going 7 for 8 for 129 yards and one TD as the Seahawks improved to 3-0.
Chad Henne passed for 235 yards but was just 18 of 38 for no touchdowns and two interceptions.
The New Orleans Saints are unbeaten after Week 3 of the NFL season. Drew Brees passed for three scores and scrambled for New Orleans' first touchdown rushing of the season in the Saints' 21-7 rout of Arizona. Brees was 29 of 46 for 342 yards, with two TD strikes to tight end Jimmy Graham and the other to Robert Meachem. Graham caught nine passes for 134 yards.
The Saints' rejuvenated defense under new coordinator Rob Ryan produced four sacks and two interceptions of Carson Palmer.
The New England Patriots are 3-0 and the Tampa Bay Bucs are 0-3. Tom Brady threw two TD passes to Kenbrell Thompkins. Thompkins, an undrafted free agent, scored on plays of 16 and 5 yards. Aaron Dobson, a second-round draft pick, finished with seven catches for 52 yards for the Patriots. New England led 17-3 at half and coasted home.
Miami is 3-0 for the first time in 11 years after Ryan Tannehill lobbed a one-yard touchdown pass to tight end Dion Sims with 38 seconds left to give the Dolphins a 27-23 win over Atlanta. Tannehill overcame five sacks and two turnovers by completing 24 of his 35 passes for 236 yards and two scores. His 13-play, 75-yard drive came after Matt Bryant missed a 35-yard field-goal attempt that would have put the Falcons ahead 26-20.
Matt Ryan threw for 231 yards and two touchdowns for the 1-2 Falcons.
The New York Giants are 0-3 after the worst defeat in Tom Coughlin's (KAWF'-lihnz) tenure as Giants coach. Cam Newton threw three touchdown passes and ran for another, and Carolina's defense sacked Eli Manning seven times in the Panthers' 38-0 rout of the Giants. It was the largest margin of victory in Panthers history, and might help save coach Ron Rivera's job following a 0-2 start. Newton had 223 yards passing and threw two touchdowns passes to Brandon LaFell and one to Ted Ginn Jr. He ran for 45 yards and his first TD of the season.
Geno Smith hit Santonio Holmes for a tiebreaking, 69-yard touchdown with 9:23 left as the New York Jets blew a 20-6 lead before beating Buffalo 27-20. Smith threw for 331 yards, two touchdowns and two interceptions for the Jets, who managed to get to 2-1 despite a team-record 20 penalties. Bilal (bih-LAL') Powell rushed for 149 yards on 27 carries to help the Jets finish with over 500 yards of total offense.
The Bills are 1-2.
Terence Newman returned a fumble 58 yards for a touchdown with 3:47 left, rallying the Cincinnati Bengals to a 34-30 victory over the Green Bay Packers. The game was a back-and-forth affair with each team committing four turnovers. The 1-2 Packers went for it on fourth-and-1 from the Cincinnati 30. Rookie Johnathan Franklin fumbled at the line and safety Reggie Nelson picked it up and started running. Aaron Rodgers stripped the ball from Nelson, but Newman scooped it up and went the final 58 yards. That improved the Bengals to 2-1.
Tennessee has its first win over the Chargers franchise since 1992 when the Titans were still in Houston after they beat San Diego 20-17. Jake Locker threw a 34-yard touchdown pass to rookie Justin Hunter with 15 seconds left for the winning score. The 2-1 Titans had lost nine straight to San Diego in a skid that spanned two states and two decades.